期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 771, 期 -, 页码 18-28出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2015.12.014
关键词
Tanshinone IIA; Experimental autoimmune encephalomyelitis; Blood-brain barrier; Adhesion molecules; Chemokines
资金
- Liaoning Province Science and Technology Project Animal Scientific Research and Clinical Application for Major Disease of Liaoning Province [2012225021]
- Program of Basic and Clinical Research Platform of China Medical University [CMU-201406]
- Technology Projects of Liaoning Province [2009225010-2]
Tanshinone IIA (TSIIA), one of the major bioactive components of the traditional Chinese herb Salvia miltiorrhiza, has been reported to have both anti-inflammatory and immunoregulatory effects. The effect of treatment with TSIIA in multiple sclerosis, an autoimmune inflammatory neurodegenerative disease, however, remains poorly understood. In the present study, experimental autoimmune encephalomyelitis (EAE), a classical experimental model of MS, was used to investigate the therapeutic effect of TSIIA. TSIIA attenuated motor dysfunction and improved inflammation and demyelination associated with EAE in a dose-dependent manner. TSIIA also significantly reduced the levels of glial fibrillary acidic protein (GFAP) and ionized calcium-binding adapter molecule-1 (Iba-1), and protected the integrity of the blood-brain barrier (BBB) by increasing the expression of critical endothelial tight junction (TJ) proteins. TSIIA also inhibited the expression of some adhesion molecules and chemokines, which are considered to be critical for adhesion of immune cells and migration across the BBB. TSIIA was thus shown to be effective in the treatment of EAE through preventing the infiltration of immune cells into the CNS, strengthening the integrity of the BBB and decreasing the numbers of adhesion molecules and chemokines. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据