期刊
STROKE
卷 52, 期 6, 页码 2035-2042出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.120.030783
关键词
ischemic stroke; lipids; prognosis
资金
- Ministry of Science and Technology of the People's Republic of China [2017YFC1307900, 2017YFC1307905, 2018YFC1312903]
- National Natural Science Foundation of China [81825007]
- Beijing Outstanding Young Scientist Program [BJJWZYJH01201910025030]
- Youth Beijing Scholar Program
- third batch of National Ten Thousand Talents Plan
- Beijing Municipal Science and Technology Commission [D171100003017002, D171100003017001]
The study suggests that non-high-density lipoprotein cholesterol may be a qualified predictor for recurrent ischemic stroke and all-cause death within 1 year in patients with acute ischemic stroke, but not predictive for intracranial hemorrhage.
Background and Purpose: Non-high-density lipoprotein cholesterol (non-HDL-C) was significantly related to adverse outcomes in patients with cardiovascular disease. We aim to investigate the associations of non-HDL-C and adverse outcomes in acute ischemic stroke. Methods: Among 19 604 patients with acute ischemic stroke admitted to the China National Stroke Registry II, 16 113 with both total cholesterol and HDL-C were analyzed. Patients were classified into 5 groups by quintiles of non-HDL-C. The outcomes included recurrent ischemic stroke, intracranial hemorrhage, and all-cause death within 1 year. The relationship of non-HDL-C with the risk of outcomes was analyzed by Cox regression models. Results: Among the 16 113 patients, the median (interquartile range) of non-HDL-C was 3.41 (2.78-4.10) mmol/L. After adjustment for confounding variables, patients in the top quintile of non-HDL-C were associated with higher risk of recurrent ischemic stroke within 1 year (adjusted hazard ratio, 1.46 [95% CI, 1.20-1.77]), compared with those in the third quintile. Patients in the bottom and top quintile of non-HDL-C were associated with higher risk of all-cause death within 1 year (adjusted hazard ratio, 1.22 [95% CI, 1.01-1.47] and adjusted hazard ratio, 1.40 [95% CI, 1.15-1.70], respectively), compared with those in the third quintile. However, non-HDL-C levels were not significantly predictive in intracranial hemorrhage. Conclusions: Non-HDL-C may be a qualified predictor for recurrent ischemic stroke and all-cause death within 1 year in patients with acute ischemic stroke.
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