期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 778, 期 -, 页码 125-138出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2015.04.046
关键词
Mast cell; Asthma; Airway diseases; Interstitial lung disease
资金
- Division of Intramural Research of NIAID
- National Institutes of Health, United States
- National Institute for Health Research Leicester Respiratory Biomedical Research Unit, United Kingdom
Mast cells are major effector cells of inflammation and there is strong evidence that mast cells play a significant role in asthma pathophysiology. There is also a growing body of evidence that mast cells contribute to other inflammatory and fibrotic lung diseases such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. This review discusses the role that mast cells play in airway diseases and highlights how mast cell microlocalisation within specific lung compartments and their cellular interactions are likely to be critical for their effector function in disease. Published by Elsevier B.V.
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