期刊
STEM CELL RESEARCH
卷 53, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scr.2021.102254
关键词
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资金
- Science Foundation Ireland [13/IA/1787]
- FutureNeuro Centre grant [16/RC/3948]
- National Children Research Centre (NCRC)
- Galway University Foundation
- China Scholarship Council (CSC)
- NUI Galway
- Irish Government's Programme for Research in Third Level Institutions, Cycle 4, National Development Plan 2007-2013
- Irish Government's Programme for Research in Third Level Institutions, Cycle 5, National Development Plan 2007-2013
- HRB-Clinical Research Facility Galway, a unit of NUI Galway
- Saolta University Health Care Group
- Science Foundation Ireland (SFI) [13/IA/1787] Funding Source: Science Foundation Ireland (SFI)
NRXN1 deletions are commonly found in ASD and other neurodevelopmental/neuropsychiatric disorders. Derivation of iPSCs from different diseases involving different deletion regions is essential for studying NRXN1's numerous splicing variants.
NRXN1 deletions are commonly found in autism spectrum disorder (ASD) and other neurodevelopmental/neuropsychiatric disorders. Derivation of induced pluripotent stem cells (iPSCs) from different diseases involving different deletion regions are essential, as NRXN1 may produce thousands of splicing variants. We report here the derivation of iPSCs from a sibling control and an ASD proband carrying de novo heterozygous deletions in the middle region of NRXN1, using a non-integrating Sendai viral kit. The genotype and karyotype of the iPSCs were validated by whole genome SNP array. All iPSC lines highly expressed pluripotency markers and could be differentiated into three germ layers.
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