期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 787, 期 -, 页码 134-142出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2016.03.064
关键词
Glaucoma; Retinal ganglion cells; Neuroinflammation; Glial cells; Neurodegeneration; Neuroprotection; Antiinflammatory
资金
- PRIN [20109MXHMR_008]
- University of Calabria
In clinical glaucoma, as well as in experimental models, the loss of retinal ganglion cells occurs by apoptosis. This final event is preceded by inflammatory responses involving the activation of innate and adaptive immunity, with retinal and optic nerve resident glial cells acting as major players. Here we review the current literature on the role of neuroinflammation in neurodegeneration, focusing on the inflammatory molecular mechanisms involved in the pathogenesis and progression of the optic neuropathy. (C) 2016 Elsevier B.V. All rights reserved.
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