4.5 Review

Tumor resident regulatory T cells

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Article Oncology

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Helena Van Damme et al.

Summary: Regulatory T cells (Tregs) play a role in antitumor immunotherapy, but lack of selectivity for tumor-infiltrating Tregs can lead to adverse effects. CCR8-specific nanobodies were developed to selectively deplete tumor-promoting Tregs in mouse and human tumors, synergizing with anti-PD-1 therapy and reducing tumor growth through NK cell-dependent mechanisms. Targeting CCR8 may be an effective and safe strategy for antitumor immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Immunology

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

Michael Delacher et al.

Summary: Research identified features of human tissue Treg cells with tissue repair functions, which show similarities in gene expression profiles at the single-cell level with murine cells, and shared characteristics with T follicular helper-like cells. Inducing differentiation of human Treg cells into Tfh-like cells can partially replicate the regenerative characteristics of tissue Treg cells.

IMMUNITY (2021)

Article Multidisciplinary Sciences

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

Clarissa Campbell et al.

NATURE (2020)

Article Multidisciplinary Sciences

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti-PD-1 in melanoma

Laurene S. Cheung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

Masanori Onda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Immunology

IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus

Saskia Hemmers et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Multidisciplinary Sciences

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody

Danbee Ha et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Elham Azizi et al.

Article Multidisciplinary Sciences

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

Ilenia Pacella et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Oncology

Roles of the RANKL-RANK axis in antitumour immunity - implications for therapy

Elizabeth Ahern et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

Silvia C. Formenti et al.

NATURE MEDICINE (2018)

Review Immunology

Regulatory T cells in skin

Niwa Ali et al.

IMMUNOLOGY (2017)

Article Immunology

A nonimmune function of T cells in promoting lung tumor progression

Jesse A. Green et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Review Biochemistry & Molecular Biology

Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer

Andrew J. Hoy et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Article Cell Biology

Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs

Subhra P. Hui et al.

DEVELOPMENTAL CELL (2017)

Article Biochemistry & Molecular Biology

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Chunhong Zheng et al.

Review Biochemistry & Molecular Biology

Metabolic Instruction of Immunity

Michael D. Buck et al.

Article Medicine, Research & Experimental

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity

Duncan Howie et al.

JCI INSIGHT (2017)

Article Immunology

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Jason D. Fontenot et al.

JOURNAL OF IMMUNOLOGY (2017)

Review Oncology

Rationale for anti-OX40 cancer immunotherapy

Sandrine Aspeslagh et al.

EUROPEAN JOURNAL OF CANCER (2016)

Article Immunology

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

Audrey Nosbaum et al.

JOURNAL OF IMMUNOLOGY (2016)

Article Immunology

An essential role for the IL-2 receptor in Treg cell function

Takatoshi Chinen et al.

NATURE IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Takuro Saito et al.

NATURE MEDICINE (2016)

Review Immunology

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

David H. Munn et al.

TRENDS IN IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

A Distinct Function of Regulatory T Cells in Tissue Protection

Nicholas Arpaia et al.

Article Immunology

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Alison M. Paterson et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Article Multidisciplinary Sciences

Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

Emanuela Romano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Immunology

Fatty acid metabolism in the regulation of T cell function

Matthias Lochner et al.

TRENDS IN IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

Madhav D. Sharma et al.

SCIENCE ADVANCES (2015)

Review Oncology

RANK-mediated signaling network and cancer metastasis

Gina Chia-Yi Chu et al.

CANCER AND METASTASIS REVIEWS (2014)

Article Biochemistry & Molecular Biology

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

Yongqiang Feng et al.

Article Immunology

Continuous requirement for the TCR in regulatory T cell function

Andrew G. Levine et al.

NATURE IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Luciana Berod et al.

NATURE MEDICINE (2014)

Article Oncology

OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients

Brendan D. Curti et al.

CANCER RESEARCH (2013)

Article Biochemistry & Molecular Biology

A Special Population of Regulatory T Cells Potentiates Muscle Repair

Dalia Burzyn et al.

Article Medicine, Research & Experimental

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

Aurelien Marabelle et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Immunology

IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

Georg Gasteiger et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Article Immunology

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

Paula D. Bos et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Article Multidisciplinary Sciences

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

E. L. Pearce et al.

SCIENCE (2013)

Editorial Material Oncology

Radiotherapy effects on anti-tumor immunity: implications for cancer treatment

Sandra Demaria et al.

FRONTIERS IN ONCOLOGY (2013)

Review Immunology

Regulatory T Cells: Mechanisms of Differentiation and Function

Steven Z. Josefowicz et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

Review Immunology

Modulation of GITR for cancer immunotherapy

David A. Schaer et al.

CURRENT OPINION IN IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Steven Z. Josefowicz et al.

NATURE (2012)

Article Multidisciplinary Sciences

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Daniela Cipolletta et al.

NATURE (2012)

Review Biotechnology & Applied Microbiology

The secret ally: immunostimulation by anticancer drugs

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Cell Biology

Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells

Michael Romio et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Oncology

Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

Jessica Godin-Ethier et al.

CLINICAL CANCER RESEARCH (2011)

Review Immunology

Becoming self-aware: the thymic education of regulatory T cells

Chan-Wang J. Lio et al.

CURRENT OPINION IN IMMUNOLOGY (2011)

Article Cell Biology

Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis

Lee M. Ocuin et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2011)

Article Multidisciplinary Sciences

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Andrea Facciabene et al.

NATURE (2011)

Article Medicine, General & Internal

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Multidisciplinary Sciences

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

Eva Gonzalez-Suarez et al.

NATURE (2010)

Review Immunology

Control of Regulatory T Cell Lineage Commitment and Maintenance

Steven Z. Josefowicz et al.

IMMUNITY (2009)

Review Oncology

Systemic effects of local radiotherapy

Silvia C. Formenti et al.

LANCET ONCOLOGY (2009)

Article Immunology

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

Silvia Piconese et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Article Multidisciplinary Sciences

In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination

Jagadeesh Bayry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

CTLA-4 control over Foxp3+ regulatory T cell function

Kajsa Wing et al.

SCIENCE (2008)

Article Multidisciplinary Sciences

Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma

Luis Vence et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4+CD25+ regulatory T cells

X. Ren et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Multidisciplinary Sciences

Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras

Noriko Komatsu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Foxp3-dependent programme of regulatory T-cell differentiation

Marc A. Gavin et al.

NATURE (2007)

Article Immunology

CD4+ CXCR4high CD69+ T cells accumulate in lung adenocarcinoma

Ori Wald et al.

JOURNAL OF IMMUNOLOGY (2006)

Correction Multidisciplinary Sciences

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development (vol 103, pg 6659, 2006)

MA Gavin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

MA Gavin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Immunology

A function for interleukin 2 in Foxp3-expressing regulatory T cells

JD Fontenot et al.

NATURE IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Free fatty acid release from human breast cancer tissue inhibits cytotoxic T-lymphocyte-mediated killing

AM Kleinfeld et al.

JOURNAL OF LIPID RESEARCH (2005)

Review Immunology

Mechanisms of suppression by suppressor T cells

H von Boehmer

NATURE IMMUNOLOGY (2005)

Article Immunology

An essential role for Scurfin in CD4+CD25+ T regulatory cells

R Khattri et al.

NATURE IMMUNOLOGY (2003)

Article Immunology

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

JD Fontenot et al.

NATURE IMMUNOLOGY (2003)

Article Multidisciplinary Sciences

Control of regulatory T cell development by the transcription factor Foxp3

S Hori et al.

SCIENCE (2003)

Article Multidisciplinary Sciences

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Y Iwai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

HD Dong et al.

NATURE MEDICINE (2002)