期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 81, 期 -, 页码 75-81出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2015.10.003
关键词
SBA-16NH(2); Surface modification; Eudragit coating; Mesalazine; Drug-carrier interaction
资金
- Bulgarian-Hungarian Inter-Academic Exchange Agreement
- Slovenian Research Agency (ARRS) [P1-0021]
SBA-16 silica was synthesized and modified by post-synthesis method with amino groups. Wet milling in acidic media was applied for loading of poorly soluble drug mesalazine (5-aminosalicylic acid -5-ASA) in different drug/carrier ratios (1: 1; 0.75: 1; 0.5: 1; 0.25: 1). The parent and drug loaded mesoporous silicas were characterized by XRD, TEM, N-2 physisorption, thermal analysis, FT-IR and solid state NMR spectroscopy. The drug loaded mesoporous systems were single-coated with Eudragit S or double-coated with Eudragit S and Eudragit RL. The polymer coating significantly modified the rate of mesalazine release from SBA-16NH(2) materials. Applying the double coating method makes possible the sustained delivery of the drug in the intestinal area avoiding the burst release in the gastric fluid. The functionalized, polymer coated mesoporous system could be considered an appropriate oral delivery system for mesalazine. In addition, reduction of mesalazine cytotoxicity on epithelial cells could be achieved by its loading into mesoporous silica particles. (C) 2015 Elsevier B.V. All rights reserved.
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