期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 13, 期 590, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.abf7517
关键词
-
资金
- Bundesministerium fur Bildung und Forschung (BMBF) [FKZ:01KI20130]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [WA 4608/1-2]
- Deutsche Forschungsgemeinschaft under Germany's Excellence Strategy [EXC2180-390900677]
- German Cancer Consortium (DKTK)
- Wilhelm Sander Stiftung [2016.177.2]
- Jose Carreras Leukamie-Stiftung [DJCLS 05 R/2017]
- Fortune Program of the University of Tubingen [2451-0-0, 2581-0-0]
The study found that antibody responses in COVID-19 convalescent individuals decreased or remained stable within 6 months, while T cell responses showed a robust increase. T cell responses included key epitopes that mediate long-term SARS-CoV-2 immunity.
Long-term immunological memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for the development of population-level immunity, which is the aim of vaccination approaches. Reports on rapidly decreasing antibody titers have led to questions regarding the efficacy of humoral immunity alone. The relevance of T cell memory after coronavirus disease 2019 (COVID-19) remains unclear. Here, we investigated SARS-CoV-2 antibody and T cell responses in matched samples of COVID-19 convalescent individuals up to 6 months after infection. Longitudinal analysis revealed decreasing and stable spike- and nucleocapsid-specific antibody responses, respectively. In contrast, functional T cell responses remained robust, and even increased, in both frequency and intensity. Single peptide mapping of T cell diversity over time identified open reading frame-independent, dominant T cell epitopes mediating longterm SARS-CoV-2 T cell responses. Identification of these epitopes may be fundamental for COVID-19 vaccine design.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据