期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 13, 期 590, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.abf7872
关键词
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资金
- American Heart Association [20POST35211143]
- National Science Foundation Graduate Research Fellowship Program
- NIH [1R01AG065428, 5DP1DA038043, U01 ES032673]
- European Research Council (ERC) [1648035]
- Roddenberry Foundation
- [R01-HL130533]
- [R01-HL135358]
- [P01-HL146366]
This study found that heart cells of COVID-19 patients exposed to SARS-CoV-2 may suffer significant damage such as myofibrillar fragmentation and nuclear disruption, providing insights for potential therapeutic discovery.
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell (iPSC)-derived heart cells to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcriptomic disruption of structural genes corroborates adverse morphologic features, which included a distinct pattern of myofibrillar fragmentation and nuclear disruption. Human autopsy specimens from patients with COVID-19 reflected similar alterations, particularly sarcomeric fragmentation. These notable cytopathic features in cardiomyocytes provide insights into SARS-CoV-2-induced cardiac damage, offer a platform for discovery of potential therapeutics, and raise concerns about the long-term consequences of COVID-19 in asymptomatic and severe cases.Y
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