期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 93, 期 -, 页码 45-55出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2016.08.007
关键词
Supercritical carbon dioxide; Omeprazole; Metolose; Buccal; Paediatric; Fast dissolving film
This study involves the development of thin oral solvent cast films for the potential delivery of the proton pump inhibitor, omeprazole (OME) via the buccal mucosa for paediatric patients. OME containing films were prepared from ethanolic gels (1% w/w) of metolose (MET) with polyethylene glycol (PEG 400) (0.5% w/w) as plasticiser, and L-arginine (L-arg) (0.2% w/w) as a stabilizer and dried in an oven at 40 degrees C. The blank and drug loaded films were divided into two groups, one group was subjected to supercritical carbon dioxide (scCO(2)) treatment and the other group untreated. The untreated and scCO(2) treated films were then characterised using differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, hydration (swelling), mucoadhesion and in vitro drug dissolution studies. Treatment of the solvent cast films with scCO(2) caused significant changes to the functional and physical properties of the MET films. The original drug loaded MET films showed a sustained release of OME (1 h), whereas scCO(2) treatment of the formulations resulted in fast dissolving films with >90% drug release within 15 min. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据