期刊
SCIENCE
卷 372, 期 6538, 页码 175-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abg5526
关键词
-
资金
- University of Chicago
- NSF [CHE-1654122]
Mild methods for cleaving the C-O bond in alkyl ethers using dibromoboranes in the presence of a nickel catalyst and zinc reductant have been shown to simplify chemical syntheses and facilitate oxygen-to-nitrogen substitution or one-carbon homologation. Mechanistic studies have revealed a cleavage-then-rebound pathway via zinc/nickel tandem catalysis.
Mild methods to cleave the carbon-oxygen (C-O) bond in alkyl ethers could simplify chemical syntheses through the elaboration of these robust, readily available precursors. Here we report that dibromoboranes react with alkyl ethers in the presence of a nickel catalyst and zinc reductant to insert boron into the C-O bond. Subsequent reactivity can effect oxygen-to-nitrogen substitution or one-carbon homologation of cyclic ethers and more broadly streamline preparation of bioactive compounds. Mechanistic studies reveal a cleavage-then-rebound pathway via zinc/nickel tandem catalysis.
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