期刊
SCHIZOPHRENIA RESEARCH
卷 231, 期 -, 页码 205-213出版社
ELSEVIER
DOI: 10.1016/j.schres.2021.03.022
关键词
Interleukin 8; IL-8; Schizophrenia; Psychosis; SSD; Neuroinflammation
类别
资金
- Ministry of Science, Research and Art Baden-Wurttemberg
The study found significantly higher IL-8 levels in the CSF of patients with schizophrenia spectrum disorders compared to the control group, supporting the hypothesis that immunological processes may be involved in the pathophysiology of some patients.
Introduction: The role of immunological mechanisms in the pathophysiology of mental disorders has been discussed with increasing frequency. In this context, especially schizophrenia has become the focus of attention after the discovery of autoimmune encephalitis, which might present with psychotic symptoms. Furthermore, multiple studies have identified associations between infections or autoimmune diseases and schizophreniform disorders. Cerebrospinal fluid (CSF) analysis plays a central role in identifying potential inflammatory processes in the central nervous system. Therefore, the rationale of this retrospective study was the analysis of different cytokines, including interleukin-8 (IL-8) levels, in the CSF of patients with schizophrenia spectrum disorders. Methods: The authors examined the CSF of 40 patients with schizophrenia spectrum disorders, in comparison to the CSF of a mentally healthy control group of 39 patients with idiopathic intracranial hypertension (IIH). Magnetic bead multiplexing immunoassay was used to retrospectively determine different cytokines in the participants' CSF. Results: Participants with schizophrenia spectrum disorders had significantly higher IL-8 levels in their CSF than controls (mean +/- SD: 41.83 +/- 17.50 pg/ml versus 21.40 +/- 7.96 pg/ml; p < 0.001). Conclusion: The main finding of this study is the presence of significantly higher IL-8 concentrations in the CSF of patients with schizophrenia spectrum disorders when compared to the control group. This supports the hypothesis that immunological processes may be involved in the pathophysiology of a subgroup of patients with schizophrenia spectrum disorders. However, the study's results are limited by the retrospective design, methodological aspects, and the control group with IIH. (c) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据