期刊
SCHIZOPHRENIA RESEARCH
卷 231, 期 -, 页码 82-89出版社
ELSEVIER
DOI: 10.1016/j.schres.2021.02.023
关键词
Schizophrenia; First episode psychosis; Early life adversity; Childhood trauma; Symptom remission
类别
资金
- NARSAD Young Investigator Award
- Golden Family Foundation
- Fonds de Rechereche du Quebec Sante (FRQS)
- Ministere de la Sante et des Services Sociaux (MSSS) [245012041]
- Canadian Institutes of Health Research (CIHR) [68961]
- FRQS
Childhood trauma can impact the positive and negative symptom remission of first episode psychosis patients over a two-year period, with effects on symptoms and global functioning observed at different time points.
Objective: Early life adversity is suspected to play an important role for onset and course of psychosis, but its relationship with longer-term clinical outcome is not entirely clear. In this longitudinal study, we investigated the impact of childhood trauma (CT) on positive and negative symptom remission in first episode psychosis (FEP) patients over two years. Methods: A total of 210 FEP patients were assessed with the Childhood Trauma Questionnaire. Patients reporting moderate to severe trauma (CT; N = 114; 54.3%) were compared to those without trauma (N-CT; N = 96; 45.7%). Positive (PSR) and negative symptom remission (NSR) were determined monthly over 24 months following established criteria using the Scale for Assessment of Positive Symptoms and the Scale for Assessment of Negative Symptoms. Global Functioning was evaluated at baseline and 24 months of follow-up. Results: Compared to N-CT patients, CT patients had achieved significantly lower rates of PSR at 12 months and significantly lower rates of NSR at 24 months. A dose-response relationship was observed between the number of trauma categories fulfilled and the number of patients not achieving PSR and NSR at these time points. Higher trauma scores were significantly associated with poor functioning and higher positive and negative symptom severity at 24 months, but not at baseline and 12 months of follow-up. Conclusion: Differential effects of CT on clinical outcome may not be apparent at psychosis onset, but only become evident through poor symptomatic remission and general functioning over time. Targeted diagnostic and therapeutic efforts after illness onset might limit these detrimental consequences. (c) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据