4.7 Article

The inflammatory role of silent urate crystal deposition in intercritical gout

期刊

RHEUMATOLOGY
卷 60, 期 11, 页码 5463-5472

出版社

OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keab335

关键词

gout; cytokine; cardiovascular diseases; inflammation

资金

  1. Grunenthal

向作者/读者索取更多资源

The study showed elevated levels of certain pro-inflammatory cytokines and metabolic proteins in intercritical gout patients. These levels were associated with estimated monosodium urate crystal deposition and cardiovascular risk factors.
Objective. To study subclinical inflammation in intercritical gout patients and its relation to the estimated size of monosodium urate crystal deposition and cardiovascular risk factors. Methods. We performed a secretome analysis and the quantification of cytokine and adipokine plasma levels [IL-1 beta, IL-18, IL-6, soluble IL-6 receptor (sIL-6R), TNF-alpha, C-X-C motif chemokine 5, RANTES (Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted), leptin, resistin and adiponectin] to analyse subclinical inflammation in intercritical gout patients. Since it is currently not feasible to determinate the whole body deposit of monosodium urate crystals, we created an indirect clinical classification to estimate it. Then we compared cytokine levels in controls and gout patients and in patients with different crystal deposition sizes. We also studied the association between cytokine-levels and the number of cardiovascular risk factors. Results. Ninety consecutive patients attending a crystal arthritis unit were studied. IL-18, sIL-6R, RANTES, leptin and adiponectin were higher in intercritical gout patients than in controls. An association was observed between IL-18, sIL6-R and RANTES levels and the size of crystal deposition. IL-18, sIL6-R, RANTES and leptin were higher in patients with no cardiovascular risk factors compared with controls with no risk factors. Conclusion. Our results showed that the levels of some pro-inflammatory cytokines and metabolic proteins are elevated in intercritical gout patients. The levels of certain cytokines were related to the estimated size of the monosodium urate crystal deposition and to the number of cardiovascular risk factors. These cytokine changes may help to explain the increase in cardiovascular events in gout patients.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据