期刊
REVIEWS IN THE NEUROSCIENCES
卷 33, 期 1, 页码 43-57出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/revneuro-2021-0038
关键词
empathy; ethnocultural; meta-analysis; oxytocin receptor; social cognition; theory of mind
资金
- National Health & Medical Research Council (NHMRC) [ID350833, ID568969, APP1093083]
- NHMRC [401184]
- Australian Research Council [DP170101239, FT170100096]
- University of New South Wales Scientia PhD Scholarship Scheme
The study showed that the rs53576 single nucleotide polymorphism is associated with cognitive empathy in Asian cohorts and affective empathy in European cohorts. G homozygotes demonstrated greater generalized empathic abilities in young to middle-aged adults.
Empathy is essential for navigating complex social environments. Prior work has shown associations between rs53576, a single nucleotide polymorphism (SNP) located in the oxytocin receptor gene (OXTR), and generalized empathy. We undertook a systematic review and meta-analysis to assess the effects of rs53576 on subdomains of empathy, specifically cognitive empathy (CE) and affective empathy (AE), in healthy adults. Twenty cohorts of 8933 participants aged 18-98 were identified, including data from the Sydney Memory and Ageing Study, a cohort of older community adults. Meta-analyses found G homozygotes had greater generalized empathic abilities only in young to middle-aged adults. While meta-analyses of empathy subdomains yielded no significant overall effects, there were differential effects based on ethnicity. G homozygotes were associated with greater CE abilities in Asian cohorts (standardized mean difference; SMD: 0.09 [2.8 center dot 10(-3)-0.18]), and greater AE performance in European cohorts [SMD: 0.12 (0.04-0.21)]. The current literature highlights a need for further work that distinguishes between genetic and ethnocultural effects and explores effects of advanced age on this relationship.
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