Generative Adversarial Networks: A Primer for Radiologists

Artificial intelligence techniques involving the use of artificial neural networks-that is, deep learning techniques-are expected to have a major effect on radiology. Some of the most exciting applications of deep learning in radiology make use of generative adversarial networks (GANs). GANs consist of two artificial neural networks that are jointly optimized but with opposing goals. One neural network, the generator, aims to synthesize images that cannot be distinguished from real images. The second neural network, the discriminator, aims to distinguish these synthetic images from real images. These deep learning models allow, among other applications, the synthesis of new images, acceleration of image acquisitions, reduction of imaging artifacts, efficient and accurate conversion between medical images acquired with different modalities, and identification of abnormalities depicted on images. The authors provide an introduction to GANs and adversarial deep learning methods. In addition, the different ways in which GANs can be used for image synthesis and image-to-image translation tasks, as well as the principles underlying conditional GANs and cycle-consistent GANs, are described. Illustrated examples of GAN applications in radiologic image analysis for different imaging modalities and different tasks are provided. The clinical potential of GANs, future clinical GAN applications, and potential pitfalls and caveats that radiologists should be aware of also are discussed in this review.

Automated summary

Artificial intelligence techniques, specifically deep learning models using generative adversarial networks (GANs), are expected to revolutionize radiology by allowing image synthesis, accelerated image acquisitions, reduced imaging artifacts, and efficient conversion between different imaging modalities. The joint optimization of two opposing artificial neural networks, the generator and the discriminator, allows for the synthesis of new images and accurate image-to-image translation. Research on GANs in radiology also explores the clinical potential, future applications, and potential risks that radiologists should be aware of.