期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2016, 期 22, 页码 3824-3835出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201600549
关键词
Synthetic methods; N-Alkylation; Chemoselectivity; C-N bond formation; Secondary amines; Cesium
资金
- Universidad de los Andes
- COLCIENCIAS
- Department of Chemistry at Universidad de los Andes
Herein is described an efficient and chemoselective method for the synthesis of diversely substituted secondary amines in yields up to 98 %. Direct mono-N-alkylation of primary benzylamines and anilines with a wide range of alkyl halides is promoted by a cesium base in the absence of any additive or catalyst. The basicity and solubility of cesium carbonate in anhydrous N, N-dimethylformamide not only enables mono-N-alkylation of primary amines but also suppresses undesired dialkylation of the desired amines.
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