期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2016, 期 8, 页码 1513-1519出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201501553
关键词
Aldol reactions; Biocatalytic promiscuity; Enzyme catalysis; Biotransformations; Deep eutectic solvents
资金
- Spanish Ministerio de Economia y Competitividad (MEC) [CTQ2013-44153-P]
- Gobierno del Principado de Asturias [FC-15-GRUPIN14-002]
- Fundacion para el fomento en Asturias de la investigacion cientifica aplicada y tecnologia (FICYT)
The application of deep eutectic solvents has been demonstrated for the first time in promiscuous lipase-catalysed aldol reactions. The model reaction between 4-nitrobenzaldehyde and acetone was examined in depth, with excellent compatibility being found between porcine pancreas lipase and choline chloride/glycerol mixtures for the formation of the aldol product in high yields. The system was compatible with a series of aromatic aldehydes and ketones including acetone, cyclopentanone and cyclohexanone. In some cases, the corresponding alpha, beta-unsaturated carbonyl compounds were found as minor products. Control experiments demonstrate that the enzymatic preparation was also responsible for a collateral dehydration reaction once the aldol product is formed.
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