期刊
PSYCHIATRY RESEARCH
卷 298, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2021.113767
关键词
Depression; Schizophrenia; Longitudinal studies; Course of illness
类别
资金
- New Partnership for Africa's Development (NEPAD) grant, through the Department of Science and Technology of South Africa
- Medical Research Council of South Africa 'SHARED ROOTS' Flagship Project [MRC-RFA-IFSP-01-2013]
- Lundbeck International
- South African Medical Research Council
Depressive symptoms are common in patients with first-episode schizophrenia spectrum disorders and show significant improvement with long-acting antipsychotic treatment. These symptoms are associated with positive symptoms, better insight, and poorer quality of life, but not with negative symptoms or extrapyramidal symptoms.
Depressive symptoms are common in schizophrenia and have been associated with both favourable and unfavourable outcomes. We studied the longitudinal course of depressive symptoms and explored their temporal relationships with other manifestations of the illness and its treatment. This longitudinal cohort study included 126 antipsychotic na?ve or only briefly treated patients with first-episode schizophrenia spectrum disorders treated with a long-acting antipsychotic over 24 months. Depressive symptoms were assessed at three monthly intervals using the Calgary Depression Scale for Schizophrenia and changes over time were assessed using linear mixed-effect models for continuous repeated measures. Depressive symptoms were most prominent at baseline with highly significant reductions during the first three months of treatment and maintenance of improvement thereafter. Most improvement occurred with antipsychotic treatment alone, with few patients requiring additional antidepressants. We also found that depressive symptoms were associated with positive symptoms, better insight and poorer quality of life, but not with negative symptoms, extrapyramidal symptoms, substance use or cumulative antipsychotic dose.There were few differences between patients who met criteria for depression during the acute phase of treatment and those in the post-acute phase.
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