期刊
PROGRESS IN LIPID RESEARCH
卷 82, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2021.101093
关键词
Antibacterial agents; Fatty acids; Non-traditional antibacterial; FA mechanisms; Multidrug-resistant bacteria
资金
- National Center for Research Resources of the National Institutes of Health [P20GM103475]
- National Institute of General Medical Sciences of the National Institutes of Health [P20GM103475]
- IAUPR-MC Seed Money
- UPR-Rio Piedras NIH-NIGMS RISE program [5R25GM061151]
The antibacterial activity of fatty acids is well-recognized and shows promise for the development of new antibacterial agents. Fatty acids play a significant role in biological defense systems against bacteria, especially in enhancing bactericidal properties when combined with other antibacterial agents. Further research is needed on the antibacterial activity, mechanisms, and biomedical applications of fatty acids.
The antibacterial activity of fatty acids (FA) is well known in the literature and represents a promising option for developing the next-generation of antibacterial agents to treat a broad spectrum of bacterial infections. FA are highly involved in living organisms' defense system against numerous pathogens, including multidrug-resistant bacteria. When combined with other antibacterial agents, the remarkable ability of FA to enhance their bactericidal properties is a critical feature that is not commonly observed in other naturally-occurring compounds. More reviews focusing on FA antibacterial activity, traditional and non-traditional mechanisms and biomedical applications are needed. This review is intended to update the reader on the antibacterial properties of recent FA and how their chemical structures influence their antibacterial activity. This review also aims to better understand both traditional and non-traditional mechanisms involved in these recently explored FA antibacterial activities.
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