期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2016, 期 20, 页码 3395-3400出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201600322
关键词
NHC ligands; Palladium; C-H activation; Acetoxylation
资金
- European Commission [MCITN-238804]
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Royal Physiographic Society in Lund
To achieve high selectivity in directed C-H activation, an NHC ligand was introduced to a palladium catalyst. A range of Pd-PEPPSI complexes were applied in the direct acetoxylation of 2-phenylpyridine. The best catalyst was found to be the one based on a diisopropylphenyl-substituted NHC ligand, and this was successfully used for the functionalization of sp(2) as well as more challenging sp(3) bonds for a broad variety of substrates. The explored method showed a highly improved selectivity compared to previously reported results with up to 96 % yield for the monoacetoxylated product. Kinetic studies show that sterics of the catalyst is less important in dictating conversion and selectivity; despite an induction period, it was shown that the catalyst is molecular in nature.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据