4.7 Article

Myosin cross-bridge kinetics slow at longer muscle lengths during isometric contractions in intact soleus from mice

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Article Biology

Myosin cross-bridge kinetics slow at longer muscle lengths during isometric contractions in intact soleus from mice

Axel J. Fenwick et al.

Summary: Muscle contraction results from force-generating interactions between myosin and actin, with factors influencing cross-bridge kinetics at the molecular level propagating through tissues to modulate whole-muscle function. Researchers found that cross-bridge kinetics vary with whole-muscle length during intact, isometric contraction, suggesting a feedback pathway between muscle function and cross-bridge activity. The study highlights the complexity of muscle contraction and the potential impact of length-dependent cross-bridge kinetics on force generation and energetics.

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