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Sangjune Kim et al.
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David R. Boyer et al.
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Chao Peng et al.
NATURE (2018)
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Iryna Prots et al.
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Ricardo Guerrero-Ferreira et al.
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Jessica M. Froula et al.
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Yaowang Li et al.
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Binsen Li et al.
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Shaoda He et al.
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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
Shawn Q. Zheng et al.
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Ignacio Inigo-Marco et al.
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Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
Marcus D. Tuttle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation
Patrick Flagmeier et al.
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Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
Marcus D. Tuttle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
CTFFIND4: Fast and accurate defocus estimation from electron micrographs
Alexis Rohou et al.
JOURNAL OF STRUCTURAL BIOLOGY (2015)
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W. Peelaerts et al.
NATURE (2015)
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
Ulf Dettmer et al.
NATURE COMMUNICATIONS (2015)
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
Petra Pasanen et al.
NEUROBIOLOGY OF AGING (2014)
Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
Diana F. Lazaro et al.
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Suzanne Lesage et al.
ANNALS OF NEUROLOGY (2013)
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Jing L. Guo et al.
CELL (2013)
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Luc Bousset et al.
NATURE COMMUNICATIONS (2013)
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Laura A. Volpicelli-Daley et al.
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli
Matthew Johnson et al.
PLOS ONE (2010)
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Jacqueline Burre et al.
SCIENCE (2010)
The physical basis of how prion conformations determine strain phenotypes
Motomasa Tanaka et al.
NATURE (2006)
Neural activity controls the synaptic accumulation of α-synuclein
DL Fortin et al.
JOURNAL OF NEUROSCIENCE (2005)
Automated electron microscope tomography using robust prediction of specimen movements
DN Mastronarde
JOURNAL OF STRUCTURAL BIOLOGY (2005)
The E46K mutation in α-synuclein increases amyloid fibril formation
EA Greenbaum et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Conformational variations in an infectious protein determine prion strain differences
M Tanaka et al.
NATURE (2004)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
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Mutation E46K increases phospholipid binding and assembly into filaments of human α-synuclein
W Choi et al.
FEBS LETTERS (2004)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)