期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2016623118
关键词
pandemic; overdispersion; mitigation strategies; superspreading; social networks
The overdispersion of COVID-19 transmission gives the virus a weakness: reducing contacts between people who do not regularly meet would significantly reduce the pandemic, while reducing repeated contacts in defined social groups would be less effective.
Increasing evidence indicates that superspreading plays a dominant role in COVID-19 transmission. Recent estimates suggest that the dispersion parameter k for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is on the order of 0.1, which corresponds to about 10% of cases being the source of 80% of infections. To investigate how overdispersion might affect the outcome of various mitigation strategies, we developed an agent-based model with a social network that allows transmission through contact in three sectors: close (a small, unchanging group of mutual contacts as might be found in a household), regular (a larger, unchanging group as might be found in a workplace or school), and random (drawn from the entire model population and not repeated regularly). We assigned individual infectivity from a gamma distribution with dispersion parameter k. We found that when k was low (i.e., greater heterogeneity, more superspreading events), reducing random sector contacts had a far greater impact on the epidemic trajectory than did reducing regular contacts; when k was high (i.e., less heterogeneity, no superspreading events), that difference disappeared. These results suggest that overdispersion of COVID-19 transmission gives the virus an Achilles' heel: Reducing contacts between people who do not regularly meet would substantially reduce the pandemic, while reducing repeated contacts in defined social groups would be less effective.
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