期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2016, 期 5, 页码 1060-1065出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201501318
关键词
Asymmetric synthesis; Diastereoselectivity; Amines; Hydrosilylation; Zinc
资金
- Polish National Science Centre [NCN 2012/07/B/ST5/00909]
An efficient zinc-catalyzed diastereoselective hydrosilylation of N-(tert-butylsulfinyl)imines has been developed that does not require the use of ligands or noble metals. A variety of N-(tert-butylsulfinyl)imines were reduced by this protocol in the presence of a catalytic amount of zinc acetate (5 mol-%) to provide the corresponding secondary amines in high yields with excellent diastereoselectivities (up to 98%de). This experimentally simple catalytic procedure is easily applicable to the synthesis of both aromatic and aliphatic amines by using triethoxysilane as an efficient hydrogen source.
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