期刊
PRENATAL DIAGNOSIS
卷 41, 期 5, 页码 620-630出版社
WILEY
DOI: 10.1002/pd.5927
关键词
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资金
- Deutsche Forschungsgemeinschaft [EXC 2067/1-390729940]
- Novo Nordisk Fonden [NNF15OC001666]
- National Institute of General Medical Sciences [R35GM133747]
- Max-Planck-Gesellschaft
- DNRF Center Grant [DNRF115]
- H2020 European Research Council [724718-ReCAP]
- Leibniz Prize
- National Institute of Child Health and Human Development [R01HD091331]
The gain or loss of a chromosome, known as aneuploidy, is a major trigger for infertility and pregnancy loss in humans. Recent studies using genomics, cytogenetics, and in silico modeling have shed new light on the potential genetic and cellular factors associated with aneuploidy at different stages of development in human oocytes and embryos.
The gain or loss of a chromosome-or aneuploidy-acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.
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