期刊
PLOS ONE
卷 16, 期 3, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0248816
关键词
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资金
- GENCI-CINES [2018-A0040307194, 2019-A0060307194]
- High Performance Computing Platform MESO@LR - Occitanie/Pyrenees-Mediterranee Region, Montpellier Mediterranean Metropole
- University of Montpellier
- ALARA Expertise
- LabEx Numev [ANR-10-LABX-0020]
- Spin Up
A numerical approach for simulating time-resolved 3D phase-contrast MRI under realistic flow conditions is presented. The Navier-Stokes and Bloch equations are solved with specific strategies to reduce computational cost. The simulated results compare favorably with experimental data.
A numerical approach is presented to efficiently simulate time-resolved 3D phase-contrast Magnetic resonance Imaging (or 4D Flow MRI) acquisitions under realistic flow conditions. The Navier-Stokes and Bloch equations are simultaneously solved with an Eulerian-Lagrangian formalism. A semi-analytic solution for the Bloch equations as well as a periodic particle seeding strategy are developed to reduce the computational cost. The velocity reconstruction pipeline is first validated by considering a Poiseuille flow configuration. The 4D Flow MRI simulation procedure is then applied to the flow within an in vitro flow phantom typical of the cardiovascular system. The simulated MR velocity images compare favorably to both the flow computed by solving the Navier-Stokes equations and experimental 4D Flow MRI measurements. A practical application is finally presented in which the MRI simulation framework is used to identify the origins of the MRI measurement errors.
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