期刊
BRAIN STRUCTURE & FUNCTION
卷 221, 期 9, 页码 4383-4398出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-015-1169-6
关键词
Schizophrenia; Neuregulin 1; Resonance; Adaptation; Synchrony; Somatosensory cortex; Endophenotypes
资金
- Schizophrenia and Autism of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) [IRTG 1328]
- Interdisciplinary Center for Clinical Research (IZKF Aachen) within the Faculty of Medicine at the RWTH Aachen University
- Fondation pour la Recherche Medicale [SPE20070709864]
- Barrel Cortex Function (BaCo-Fun) research group of the DFG
- Helmholtz association
- National Institute of Health (NIH) [MH064045, P50-MH096891, R01 EY020765]
To reveal the neuronal underpinnings of sensory processing deficits in patients with schizophrenia, previous studies have investigated brain activity in response to sustained sensory stimulation at various frequencies. This paradigm evoked neural activity at the stimulation frequency and harmonics thereof. During visual and auditory stimulation that elicited enhanced or 'resonant' responses in healthy controls, patients with schizophrenia displayed reduced activity. The present study sought to elucidate the cellular basis of disease-related deficits in sensory resonance properties using mice heterozygous for the schizophrenia susceptibility gene Neuregulin 1 (NRG1). We applied repetitive whisker stimulation at 1-15 Hz, a range relevant to whisking behavior in mice, and measured cellular activity in the primary somatosensory cortex. At frequencies where control mice displayed enhancements in measures of response magnitude and precision, NRG1 (+/-) mutants showed reductions. Our results demonstrate for the first time a link between a mutation of a schizophrenia risk gene and altered neuronal resonance properties in sensory cortex.
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