期刊
PHYTOTHERAPY RESEARCH
卷 35, 期 9, 页码 4782-4794出版社
WILEY
DOI: 10.1002/ptr.7110
关键词
apoptosis; cancer; proliferation; systematic review; Theanine; γ ‐ Glutamilethylamid
资金
- Student Research Committee, Tabriz University of Medical Sciences [66358]
Theanine, a unique nonprotein derivative amino acid found in tea and nonedible mushrooms, shows promising anticancer effects by affecting apoptosis, metastasis, migration, and proliferation in cancer cell lines. In vivo studies also support its potential impacts on cancer. Theanine exerts its function by inhibiting various pathways and activating apoptosis, providing a basis for further research on its effectiveness in cancer prevention and treatment mechanisms.
A growing literature indicates several health benefits of theanine, a major nonprotein derivative amino acid special to tea, and a nonedible mushroom. This study aimed to systematically review the scientific evidence regarding the anticarcinogen and anticancer effects of natural theanine. A systematic search for the relevant articles published until January 2021 on MEDLINE, Scopus, and Web of Knowledge was conducted. Out of 377 initial records, 14 in vitro, ex vivo, and in vivo studies met our inclusion criteria. Most of the included in vitro and ex vivo studies reported beneficial effects of theanine on the proliferation, apoptosis, metastasis, migration, and invasion in various cancer cell lines. The in vivo studies also supported the potential impacts of theanine on cancer incidence or progression. Theanine exerted its anticancer function by inhibiting EGFR, VEGFR, Met, and Akt/mTOR, JAK2/STAT3, and ERK/NF kappa B pathways, as well as activating the intrinsic apoptosis pathway and caspase-independent programmed cell death. In conclusion, the results indicated moderate apoptotic, antimetastatic, antimigration, and anti-invasion effects, along with the mild antiproliferative influence of theanine on cancer. Further studies are necessary to ascertain the effectiveness of theanine on the prevention and suppression of cancer and shed light upon the attributable mechanisms in the in vivo condition.
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