期刊
PHYTOTHERAPY RESEARCH
卷 35, 期 6, 页码 3418-3427出版社
WILEY
DOI: 10.1002/ptr.7064
关键词
anti‐ oxidation; atherosclerosis; black tea; Nrf2; theaflavins
资金
- Fundamental Research Funds for the Central Universities [XDJK2020D030]
The study demonstrated that TF can decrease serum lipid levels, increase the activity of antioxidant enzymes, and inhibit atherosclerotic plaque formation in mice. In vitro, TF was shown to protect endothelial cells from oxidative damage.
Theaflavin (TF) in black tea has been shown to have significant antioxidant and anti-inflammatory capacity; however, the effects and the underlying mechanism of TF on atherosclerosis (AS) remain unclear. Herein, we investigated the effects and the potential mechanism of TF on AS progression in vivo and in vitro. ApoE(-/-) mice were administrated with high fat diet (HFD) or HFD + TF (5 or 10 mg, i.g.) for 12 weeks. The results indicated that TF administration effectively decreases the serum lipid levels and the production of MDA in HFD-fed mice. Meanwhile, TF promotes the activities of antioxidant enzymes (SOD, CAT, and GSH-Px) and inhibits the formation of atherosclerotic plaque and the process of histological alterations in the aorta. In vitro, TF pretreatment could protect against cholesterol-induced oxidative injuries in HUVEC cells, decreasing the level of ROS and MDA, maintaining the activities of antioxidant enzymes. Further study revealed that TF upregulates Nrf2/HO-1 signaling pathway in vascular endothelial cells. Moreover, TF increases the level of microRNA-24 (miR-24), and miR-24 inhibition markedly compromises TF-induced Nrf2 activation and protective effects. In conclusion, the present study indicated that theaflavins may achieve the anti-atherosclerotic effect via activating miR-24-mediated Nrf2/HO-1 signaling pathway.
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