期刊
PHYTOCHEMISTRY
卷 185, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2021.112701
关键词
Desert plant; Artemisia desterorum; Asteraceae; Endophytic fungus; Chaetomium globosum; Chaetomiaceae; Globosumin; Globosumone; Bioactivities
资金
- CAMS Initiative for Innovative Medicine [2017-I2M-4-004]
- Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources [2060302-1904-30]
- National Major Increase or Decrease Project-Construction of the Sustainable Utilization Capacity of Famous Traditional Chinese Medicine Resources [2060302]
New metabolites globosumin and globosumone were isolated from the endophytic fungus Chaetomium globosum, showing inhibitory effects on Arabidopsis thaliana seedling growth and cancer cell lines A549 and HepG2, with Chaetoglobosin A demonstrating dose-dependent biological activity.
Globosumin, an undescribed chromene-4,7(4aH)-dione-tetramic acid PKS-PKS-NRPS hybrid, and globosumone, an undescribed azaphilone, together with ten known metabolites, were isolated from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae). The planar structures and relative configurations of globosumin and globosumone were determined by high-resolution ESI-MS and NMR data, and the absolute configurations of these two metabolites were determined by electronic circular dichroism (ECD) and circular dichroism (CD) combined with time-dependent density functional theory (TDDFT)-based quantum-chemical calculations. Chaetoglobosin A displayed biological effects against the seedling growth of Arabidopsis thaliana (Brassicaceae) in a dose-dependent manner, and this compound also exhibited biological activity against two cancer cell lines, A549 and HepG2, with IC50 values of 6.82 +/- 2.34 and 38.62 +/- 7.44 mu M, respectively.
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