期刊
PHYSIOLOGICAL MEASUREMENT
卷 42, 期 4, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1361-6579/abf1af
关键词
dynamic cerebral autoregulation; transfer function analysis; cerebral blood flow; transcranial Doppler ultrasound; validity; reliability
资金
- Canadian Foundation for Innovation [30979]
- Mitacs [IT03862]
- Natural Sciences and Engineering Research Council [1274829, 464009, 477210]
- Innovations in Wellness Fund [65R25912]
- Ministere de l'Education, du Loisir et du Sport du Quebec
- Foundation of the Institut universitaire de cardiologie et de pneumologie de Quebec
- Osteopathie Quebec
- Fondation Canadienne pour lEnseignement et la Recherche en Osteopathie
- Canadian Institutes of Health Research
- Societe quebecoise d'hypertension arterielle
- Research Center of the IUCPQ
The study showed that valid and reliable dynamic cerebral autoregulation estimates can be obtained from shorter recording durations of squat-stand maneuvers, such as 180 or 240 seconds, when physiological covariates are controlled. However, future studies should aim for 300-second recordings to ensure optimal results.
Objective. Currently, a recording of 300 s is recommended to obtain accurate dynamic cerebral autoregulation estimates using transfer function analysis (TFA). Therefore, this investigation sought to explore the concurrent validity and the within- and between-day reliability of TFA estimates derived from shorter recording durations from squat-stand maneuvers. Approach. Retrospective analyses were performed on 70 young, recreationally active or endurance-trained participants (17 females; age: 26 +/- 5 years, [range: 20-39 years]; body mass index: 24 +/- 3 kg m(-2)). Participants performed 300 s of squat-stands at frequencies of 0.05 and 0.10 Hz, where shorter recordings of 60, 120, 180, and 240 s were extracted. Continuous transcranial Doppler ultrasound recordings were taken within the middle and posterior cerebral arteries. Coherence, phase, gain, and normalized gain metrics were derived. Bland-Altman plots with 95% limits of agreement (LOA), repeated measures ANOVA's, two-tailed paired t-tests, coefficient of variation, Cronbach's alpha, intraclass correlation coefficients, and linear regressions were conducted. Main results. When examining the concurrent validity across different recording durations, group differences were noted within coherence (F ((4155)) > 11.6, p < 0.001) but not phase (F ((4155)) < 0.27, p > 0.611), gain (F ((4155)) < 0.61, p > 0.440), or normalized gain (F ((4155)) < 0.85, p > 0.359) parameters. The Bland-Altman 95% LOA measuring the concurrent validity, trended to narrow as recording duration increased (60 s: < +/- 0.4, 120 s: < +/- 0.3, 180 s < +/- 0.3, 240 s: < +/- 0.1). The validity of the 180 and 240 s recordings further increased when physiological covariates were included within regression models. Significance. Future studies examining autoregulation should seek to have participants perform 300 s of squat-stand maneuvers. However, valid and reliable TFA estimates can be drawn from 240 s or 180 s recordings if physiological covariates are controlled.
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