4.6 Article

Scalable electronic readout design for a 100 ps coincidence time resolution TOF-PET system

期刊

PHYSICS IN MEDICINE AND BIOLOGY
卷 66, 期 8, 页码 -

出版社

IOP PUBLISHING LTD
DOI: 10.1088/1361-6560/abf1bc

关键词

positron emission tomography; coincidence time resolution; time-of-flight; scintillation crystal; silicon photomultipliers; front-end electronics; FPGA-based TDC

资金

  1. NIH [5R01CA21466903, 1R01EB02512501]
  2. National Research Foundation of Korea [NRF-2016R1A2B3014645]
  3. VALi+d Program for Researchers in Postdoctoral Phase of the Ministry of Labor and Social Economy (Generalitat de Valencia)
  4. European Social Fund
  5. China Scholarship Council
  6. National Research Foundation of Korea [2016R1A2B3014645] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

A scalable detector readout design was developed for a 100 ps coincidence time resolution (CTR) time of flight (TOF) PET detector using 'fast-LGSO:Ce' scintillation crystals and SiPMs. Experimental results demonstrated a CTR of 102.03 +/- 1.9 ps achieved with single crystal elements and 113.4 +/- 0.7 ps with crystal arrays. The goal is to create the first TOF-PET system with 100 ps FWHM CTR using the presented readout architecture.
We have developed a scalable detector readout design for a 100 ps coincidence time resolution (CTR) time of flight (TOF) positron emission tomography (PET) detector technology. The basic scintillation detectors studied in this paper are based on 2 x 4 arrays of 3 x 3 x 10 mm(3) 'fast-LGSO:Ce' scintillation crystals side-coupled to 6 x 4 arrays of 3 x 3 mm(2) silicon photomultipliers (SiPMs). We employed a novel mixed-signal front-end electronic configuration and a low timing jitter Field Programming Gate Array-based time to digital converter for data acquisition. Using a Na-22 point source, >10 000 coincidence events were experimentally acquired for several SiPM bias voltages, leading edge time-pickoff thresholds, and timing channels. CTR of 102.03 +/- 1.9 ps full-width-at-half-maximum (FWHM) was achieved using single 3 x 3 x 10 mm(3) 'fast-LGSO' crystal elements, wrapped in Teflon tape and side coupled to a linear array of 3 SiPMs. In addition, the measured average CTR was 113.4 +/- 0.7 ps for the side-coupled 2 x 4 crystal array. The readout architecture presented in this work is designed to be scalable to large area module detectors with a goal to create the first TOF-PET system with 100 ps FWHM CTR.

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