期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 205, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2021.173189
关键词
High fructose corn syrup; Reward; Pharmacology; Oxycodone; Animals
资金
- Natural Sciences and Engineering Research Council (NSERC)
- NSERC
- Canadian Institutes of Health Research (CIHR)
The study suggests that dietary sugars may affect vulnerability to opioid abuse. The findings indicate that high fructose corn syrup may increase place preference induced by oxycodone, enhance its suppressant effect on locomotion, and attenuate its elevation in dopamine overflow in the NAc.
There are indications that sugars in the diet can play a role in vulnerability to opioid abuse. The current study examined a range of neuro-behavioural interactions between oxycodone (OXY) and high fructose corn syrup (HFCS). Male Sprague-Dawley rats had access to HFCS (0 or 50%) over 26 days in their home cages and were subsequently tested on place conditioning induced by 0, 0.16 and 2.5 mg/kg OXY (3 pairings of drug and saline, each 30 min), as well as on locomotor responses to 0, 0.16 and 2.5 mg/kg OXY, and in-vivo microdialysis was employed to measure dopamine (DA) levels in the nucleus accumbens (NAc) in response to 0 and 2.5 mg/kg OXY. A complex set of interactions between HFCS exposure and responses to OXY were observed: HFCS increased place preference induced by OXY, it enhanced the suppressant effect of OXY on locomotion, and it attenuated OXY-induced elevation in DA overflow in the NAc. Taken together, these findings suggest that nutrition has the potential to influence some responses to opioids which may be relevant to their abuse.
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