4.7 Review

The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics

期刊

PHARMACOLOGY & THERAPEUTICS
卷 227, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2021.107881

关键词

TRIM; Cancer; Prognosis; Diagnosis; Inhibitor; Therapeutic targets

资金

  1. Projects for College Students in Henan University [2020101901]
  2. National Natural Science Foundation of China [U2004136]
  3. program for Innovative Talents of Science and Technology in Henan Province [18HASTIT048]
  4. Henan University [2018YLJC01, 2019YLXKJC01, 2020YLZDYJ14]
  5. Central Plain Young Top Talents [ZYQR201912176]

向作者/读者索取更多资源

This article discusses the significance of TRIM proteins in regulating the biological behaviors of cancer cells, highlighting the potential of certain TRIM family members as molecular biomarkers for cancer diagnosis and therapy.
Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM) family, with E3 ubiq-uitin ligase activities in majority of its members, is reported to be involved in multiple cellular processes and sig-naling pathways. TRIM proteins have critical effects in the regulation of biological behaviors of cancer cells. Here, we discussed the current understanding of the molecular mechanism of TRIM proteins regulation of cancer cells. We also comprehensively reviewed published studies on TRIM family members as oncogenes or tumor suppres-sors in the oncogenesis, development, and progression of a variety of types of human cancers. Finally, we highlighted that certain TRIM family members are potential molecular biomarkers for cancer diagnosis and prog-nosis, and potential therapeutic targets. (c) 2021 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据