期刊
PHARMACOLOGICAL RESEARCH
卷 165, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105432
关键词
Heart failure; Cardiac remodeling; Sirtuins; SIRT3
资金
- National Natural Science Foundation of China [2017YF010503]
Heart failure is a major global disease, and SIRT3 plays a significant role in cardiac diseases, protecting cardiomyocytes from various types of damage and regulating cell survival. The potential therapeutic use of SIRT3 as a target for heart failure treatment is discussed.
Heart failure causes significant morbidity and mortality worldwide. The underlying mechanisms and pathological changes associated with heart failure are exceptionally complex. Despite recent advances in heart failure research, treatment outcomes remain poor. The sirtuin family member sirtuin-3 (SIRT3) is involved in several key biological processes, including ATP production, catabolism, and reactive oxygen species detoxification. In addition to its role in metabolism, SIRT3 regulates cell death and survival and has been implicated in the pathogenesis of cardiovascular diseases. Emerging evidence also shows that SIRT3 can protect cardiomyocytes from hypertrophy, ischemia-reperfusion injury, cardiac fibrosis, and impaired angiogenesis. In this review article, we summarize the recent advances in SIRT3 research and discuss the role of SIRT3 in heart failure. We also discuss the potential use of SIRT3 as a therapeutic target in heart failure.
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