期刊
PHARMACOLOGICAL RESEARCH
卷 167, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105484
关键词
HDAC; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; DNA methylation; Histone modification; MicroRNAs
资金
- All India Council for Technical Education (AICTE), Government of India, New Delhi [AICTE/NDF/53120]
NAFLD has become a significant health concern globally due to its rapid prevalence increase and association with metabolic syndrome. Lifestyle changes and drug treatments are currently the main strategies for NAFLD management. The emerging field of epigenetics provides new insights into understanding the pathogenesis of NAFLD, offering opportunities for targeting disease prevention and novel therapeutic interventions through regulating epigenetic modifications.
Recently non-alcoholic fatty liver disease (NAFLD) has grabbed considerable scientific attention, owing to its rapid increase in prevalence worldwide and growing burden on end-stage liver diseases. Metabolic syndrome including obesity, diabetes, and hypertension poses a grave risk to NAFLD etiology and progression. With no drugs available, the mainstay of NAFLD management remains lifestyle changes with exercise and dietary modifications. Nonselective drugs such as metformin, thiazolidinediones (TZDs), ursodeoxycholic acid (UDCA), silymarin, etc., are also being used to target the interrelated pathways for treating NAFLD. Considering the enormous disease burden and the unmet need for drugs, fresh insights into pathogenesis and drug discovery are required. The emergence of the field of epigenetics offers a convincing explanation for the basis of lifestyle, environmental, and other risk factors to influence NAFLD pathogenesis. Therefore, understanding these epigenetic modifications to target the primary cause of the disease might prove a rational strategy to prevent the disease and develop novel therapeutic interventions. Apart from describing the role of epigenetics in the pathogenesis of NAFLD as in other reviews, this review additionally provides an elaborate discussion on exploiting the high plasticity of epigenetic modifications in response to environmental cues, for developing novel therapeutics for NAFLD. Besides, this extensive review provides evidence for epigenetic mechanisms utilized by several potential drugs for NAFLD.
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