Contrast-enhanced ultrasound of the kidneys and adrenals in children

Pediatric applications of contrast-enhanced ultrasound (CEUS) are growing. Evaluation of the kidneys and adrenal glands in children using intravenous administration of US contrast agents, however, is still an off-label indication. Pediatric CEUS applications for kidneys are similar to those in adults, including ischemic disorders, pseudo- versus real tumors, indeterminate lesions, complex cystic lesions, complicated pyelonephritis, and abscesses. CEUS applications for evaluation of adrenal glands in children are limited, mainly focusing on the assessment and follow-up of adrenal trauma and the differentiation between an adrenal hemorrhage and a mass. This review addresses the current experience in pediatric CEUS of the kidneys and adrenal glands. By extrapolating the established knowledge for US contrast evaluations in the adult kidney to the pediatric context we can note opportunities for CEUS clinical use in children.

Automated summary

The pediatric applications of CEUS for kidneys and adrenal glands are expanding, with a focus on evaluating ischemic disorders, tumor differentiation, cystic lesions, pyelonephritis, and trauma. The use of CEUS in children remains off-label for intravenous administration of US contrast agents but shows potential for clinical utilization by extrapolating adult kidney evaluation knowledge to the pediatric context.