期刊
PEDIATRIC ALLERGY AND IMMUNOLOGY
卷 32, 期 6, 页码 1238-1254出版社
WILEY
DOI: 10.1111/pai.13516
关键词
asthma; allergy; bronchial hyperresponsiveness; growth; lung function; small airways
This systematic review found that factors such as asthma, wheezing, bronchial hyper-responsiveness, and early-life allergic sensitization can impact the development of large and small airway lung function in early childhood, potentially leading to lower levels of lung function growth. However, in later childhood, even with the presence of asthma or wheezing, lung function development continues at a lower level but largely tracks parallel to individuals without these conditions.
Background It is unclear in which periods of life lung function deficits develop, and whether these are affected by risk factors such as asthma, bronchial hyper-responsiveness (BHR) and allergic comorbidity. The goal of this systematic review was to identify temporal associations of asthma, BHR and allergic comorbidity with large and small lung function development from birth until peak function in early adulthood. Methods We searched MEDLINE, EMBASE, Web of Science and CINAHL for papers published before 01.01.2020 on risk factors and lung function measurements of large and small airways. Studies were required to report lung function at any time point or interval from birth until peak lung function (age 21-26) and include at least one candidate risk factor. Results Of the 45 papers identified, 44 investigated cohorts and one was a clinical trial with follow-up. Asthma, wheezing, BHR and allergic sensitization early in life and to multiple allergens were associated with a lower lung function growth of large and small airways during early childhood compared with the control populations. Lung function development after childhood in subjects with asthma or persistent wheeze, although continuing to grow at a lower level, largely tracked parallel to non-affected individuals until peak function was attained. Clinical implications and future research Deficits in lung function growth develop in early childhood, and children with asthma, BHR and early-life IgE (poly)sensitization are at risk. This period is possibly a critical window of opportunity to identify at-risk subjects and provide treatment aimed at preventing long-term sequelae of lung function.
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