期刊
PARASITOLOGY
卷 148, 期 10, 页码 1219-1222出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182021000482
关键词
Nuclear tRNA export; Trypanosoma brucei; tRNA modification
类别
资金
- Czech Science Foundation [20-11585S]
- ERDF/ESF project Centre for Research of Pathogenicity and Virulence of Parasites [CZ.02.1.01/0.0/0.0/16 019/0000759]
Transfer RNAs play a crucial role in protein synthesis and undergo extensive processing before leaving the nucleus for translation. This includes removal of end and/or exonucleases, addition of CCA tails, posttranscriptional modifications, and sometimes intron removal. Evolutionary conservation and diversity of nuclear tRNA export mechanisms are highlighted through comparisons between opisthokonts and excavates.
Transfer RNAs play a key role in protein synthesis. Following transcription, tRNAs are extensively processed prior to their departure from the nucleus to become fully functional during translation. This includes removal of 5 ' leaders and 3 ' trailers by a specific endo- and/or exonuclease, 3 ' CCA tail addition, posttranscriptional modifications and in some cases intron removal. In this minireview, the critical factors of nuclear tRNA trafficking are described based on studies in classical models such as yeast and human cell lines. In addition, recent findings and identification of novel regulatory loops of nuclear tRNA trafficking in trypanosomes are discussed with emphasis on tRNA modifications. The comparison between the representatives of opisthokonts and excavates serves here to understand the evolutionary conservation and diversity of nuclear tRNA export mechanisms.
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