4.3 Article

Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Toxicology

Induction of cell cycle arrest and apoptosis by tomentosin in hepatocellular carcinoma HepG2 and Huh7 cells

S. H. Yu et al.

Summary: Tomentosin, a sesquiterpene lactone, exhibited cytotoxic effects on human HCC cell lines HepG2 and Huh7 by inducing cell cycle arrest and apoptosis. This study suggested that Tomentosin could be a promising therapeutic option against HCC.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

Article Environmental Sciences

6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53

Yong Jun Choi et al.

Summary: 6,8-Diprenylorobol inhibits proliferation of LoVo and HCT15 colon cancer cells in a dose- and time-dependent manner. It activates p53 and generates ROS, leading to decreased cell viability and increased apoptotic cell portion.

ENVIRONMENTAL TOXICOLOGY (2021)

Review Gastroenterology & Hepatology

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

Mingyang Song et al.

GASTROENTEROLOGY (2020)

Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Oncology

p27 as a Transcriptional Regulator: New Roles in Development and Cancer

Seyedeh Fatemeh Razavipour et al.

CANCER RESEARCH (2020)

Article Biotechnology & Applied Microbiology

Cytoplasmic p27 is a novel prognostic biomarker and oncogenic protein for nasopharyngeal carcinoma

Yaoshu Teng et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species

Chang Min Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Oncology

Shikonin derivatives for cancer prevention and therapy

Joelle C. Boulos et al.

CANCER LETTERS (2019)

Review Oncology

Early colorectal cancer: diagnosis, treatment and survivorship care

Gabriella Buccafusca et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

Article Multidisciplinary Sciences

p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma

Arthur W. Currier et al.

SCIENTIFIC REPORTS (2019)

Review Oncology

Phytochemicals in Anticancer Drug Development

Rohit Dutt et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2019)

Review Nutrition & Dietetics

Colorectal Cancer and Nutrition

Kannan Thanikachalam et al.

NUTRIENTS (2019)

Review Gastroenterology & Hepatology

Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors

Prashanth Rawla et al.

GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY (2019)

Article Food Science & Technology

Indole-3-carbinol induces apoptosis in human hepatocellular carcinoma Huh-7 cells

Chang Min Lee et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

Review Oncology

Re-evaluating the role of FOXOs in cancer

M. Hornsveld et al.

SEMINARS IN CANCER BIOLOGY (2018)

Review Biochemistry & Molecular Biology

FOXO Signaling Pathways as Therapeutic Targets in Cancer

Mohd Farhan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Article Dentistry, Oral Surgery & Medicine

Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis

Da Jeong Kim et al.

ARCHIVES OF ORAL BIOLOGY (2016)

Article Food Science & Technology

Genistein induces apoptosis by down-regulating thioredoxin-1 in human hepatocellular carcinoma SNU-449 cells

Taylor Roh et al.

FOOD AND CHEMICAL TOXICOLOGY (2016)

Article Biochemistry & Molecular Biology

Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity

Seok-Cheol Cho et al.

BIOMOLECULES & THERAPEUTICS (2015)

Review Geriatrics & Gerontology

FOXO3: A Major Gene for Human Longevity - A Mini-Review

Brian J. Morris et al.

GERONTOLOGY (2015)

Article Biochemistry & Molecular Biology

FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis

Jiao Wang et al.

APOPTOSIS (2015)

Review Cell Biology

FOXOs: signalling integrators for homeostasis maintenance

Astrid Eijkelenboom et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Cell Biology

FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3

Judith Hagenbuchner et al.

JOURNAL OF CELL SCIENCE (2012)

Article Multidisciplinary Sciences

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

Young Min Chung et al.

NATURE COMMUNICATIONS (2012)

Review Biochemistry & Molecular Biology

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

Guri Tzivion et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Review Biochemistry & Molecular Biology

Akt, FoxO and regulation of apoptosis

Xinbo Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Article Gastroenterology & Hepatology

Inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo

Yun Zeng et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Article Integrative & Complementary Medicine

Shiunko and acetylshikonin promote reepithelialization, angiogenesis, and granulation tissue formation in wounded skin

Pao-Ju Lu et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

Kazuyuki Yamagata et al.

MOLECULAR CELL (2008)

Review Biochemistry & Molecular Biology

The FoxO code

D. R. Calnan et al.

ONCOGENE (2008)

Article Pharmacology & Pharmacy

Shikonin, Acetylshikonin, and Isobutyroylshikonin Inhibit VEGF-induced Angiogenesis and Suppress Tumor Growth in Lewis Lung Carcinoma-bearing Mice

Hyo-Jung Lee et al.

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN (2008)

Article Biochemistry & Molecular Biology

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

Eric L. Greer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Cell Biology

Dynamic FoxO transcription factors

Haojie Huang et al.

JOURNAL OF CELL SCIENCE (2007)

Article Cell Biology

Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1

Sachie Asada et al.

CELLULAR SIGNALLING (2007)

Article Oncology

Physical activity and survival after colorectal cancer diagnosis

Jeffrey A. Meyerhardt et al.

JOURNAL OF CLINICAL ONCOLOGY (2006)

Article Plant Sciences

Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon

K Touno et al.

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2005)

Article Multidisciplinary Sciences

Proteasomal degradation of the Fox01 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

M Aoki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Cell Biology

Caspases, apoptosis and aging

JH Zhang et al.

AGEING RESEARCH REVIEWS (2003)

Article Biochemistry & Molecular Biology

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

DR Plas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Biochemistry & Molecular Biology

Molecular mechanisms of N-acetylcysteine actions

M Zafarullah et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2003)

Article Cell Biology

Are p27 and p21 Cytoplasmic Oncoproteins?

Mikhail V. Blagosklonny

CELL CYCLE (2002)

Article Biochemistry & Molecular Biology

Initiator caspases in apoptosis signaling pathways

M Chen et al.

APOPTOSIS (2002)