4.3 Review

Melatonin to Rescue the Aged Heart: Antiarrhythmic and Antioxidant Benefits

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Toxicology

Melatonin attenuates chemical-induced cardiotoxicity

S. Zare et al.

Summary: Melatonin acts as a protector against cardiotoxicity by scavenging free radicals and functioning as an antioxidant. The identified mechanisms of melatonin and its benefits in various cardiac pathophysiological disorders have been demonstrated in different model systems. Its therapeutic potential for cardiovascular toxicity continues to attract attention.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

Review Biochemistry & Molecular Biology

Cardiac Connexin-43 Hemichannels and Pannexin1 Channels: Provocative Antiarrhythmic Targets

Katarina Andelova et al.

Summary: Cardiac connexin-43 and pannexin1 channels play crucial roles in intercellular communication and are active under stressful conditions. Activation of these channels may disrupt intracellular ion balance and redox state, affecting inflammatory and fibrotic processes, thereby increasing the risk of arrhythmias.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Editorial Material Endocrinology & Metabolism

Journal of pineal research guideline for authors: Defining and characterizing melatonin targets

Erika Cecon et al.

Summary: Melatonin has been associated with a multitude of effects at varying concentrations, with over fifteen proposed targets. The current guidelines aim to provide a framework for improving and rationalizing the characterization of melatonin targets and effects, acting as mandatory guidelines for manuscripts submitted to the Journal of Pineal Research.

JOURNAL OF PINEAL RESEARCH (2021)

Review Physiology

Cardiac Pacemaker Activity and Aging

Colin H. Peters et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 82 (2020)

Article Biochemistry & Molecular Biology

Structural insights into melatonin receptors

Benjamin Stauch et al.

FEBS JOURNAL (2020)

Article Biochemistry & Molecular Biology

Reperfusion Arrhythmias Increase after Superior Cervical Ganglionectomy Due to Conduction Disorders and Changes in Repolarization

Natalia Jorgelina Prado et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, Research & Experimental

Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy

Eric Himelman et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Cardiac & Cardiovascular Systems

Cellular cross-talks in the diseased and aging heart

Julian U. G. Wagner et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Review Endocrinology & Metabolism

Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments

Xiaoqiang Tang et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Review Cell Biology

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging

Yue Quan et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Review Medicine, Research & Experimental

Cardioprotective effects of melatonin: Focusing on its roles against diabetic cardiomyopathy

Yan-Jun Song et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

Interrelation between ROS and Ca2+ in aging and age-related diseases

Corina T. Madreiter-Sokolowski et al.

REDOX BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

Marisol Fernandez-Ortiz et al.

ANTIOXIDANTS (2020)

Review Biochemistry & Molecular Biology

Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks

Ruediger Hardeland

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

Linda C. Johansson et al.

NATURE (2019)

Article Multidisciplinary Sciences

Structural basis of ligand recognition at the human MT1 melatonin receptor

Benjamin Stauch et al.

NATURE (2019)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and oxidative stress in heart disease

Jessica N. Peoples et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Review Pharmacology & Pharmacy

Is There Sufficient Evidence that the Melatonin Binding Site MT3 Is Quinone Reductase 2?

Jean A. Boutin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Article Biochemistry & Molecular Biology

Association Between Antiarrhythmic, Electrophysiological, and Antioxidative Effects of Melatonin in Ischemia/Reperfusion

Ksenia A. Sedova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Geriatrics & Gerontology

Integration of Melatonin Related Redox Homeostasis, Aging, and Circadian Rhythm

Karolin Yanar et al.

REJUVENATION RESEARCH (2019)

Article Medicine, Research & Experimental

Transcriptions heterogeneity of fibroblasts is a hallmark of the aging heart

Ramon Vidal et al.

JCI INSIGHT (2019)

Article Pharmacology & Pharmacy

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Nava Zisapel

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation

Yung-Kuo Lin et al.

CIRCULATION JOURNAL (2018)

Review Medicine, Research & Experimental

The aging heart

Vanessa Obas et al.

CLINICAL SCIENCE (2018)

Article Pharmacology & Pharmacy

Emerging pharmacotherapies for the treatment of atrial fibrillation

Alessandro Capucci et al.

EXPERT OPINION ON EMERGING DRUGS (2018)

Article Neurosciences

Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation

Samantha D. Francis Stuart et al.

JOURNAL OF PHYSIOLOGY-LONDON (2018)

Article Endocrinology & Metabolism

Antiarrhythmic effect linked to melatonin cardiorenal protection involves AT1 reduction and Hsp70-VDR increase

Natalia Jorgelina Prado et al.

JOURNAL OF PINEAL RESEARCH (2018)

Review Endocrinology & Metabolism

Melatonin and cardioprotection against ischaemia/reperfusion injury: What's new? A review

Amanda Lochner et al.

JOURNAL OF PINEAL RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Arrhythmias in Patients ≥80 Years of Age Pathophysiology, Management, and Outcomes

Anne B. Curtis et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Multidisciplinary Sciences

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

Rafael Radi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Geriatrics & Gerontology

Oxidative stress, aging, and diseases

Ilaria Liguori et al.

CLINICAL INTERVENTIONS IN AGING (2018)

Review Physiology

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

Zukiswa Jiki et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Immunology

Age and Age-Related Diseases: Role of inflammation Triggers and Cytokines

Irene Maeve Rea et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Melatonin in Heart Failure: A Promising Therapeutic Strategy?

Frederic Nduhirabandi et al.

MOLECULES (2018)

Review Pharmacology & Pharmacy

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Bee Ling Tan et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Peripheral Vascular Disease

Mitochondrial oxidative stress and cardiac ageing

Beatriz Martin-Fernandez et al.

CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS (2018)

Review Medicine, General & Internal

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Claudio Franceschi et al.

FRONTIERS IN MEDICINE (2018)

Article Pharmacology & Pharmacy

Melatonin receptors: molecular pharmacology and signalling in the context of system bias

Erika Cecon et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Sleep Medications Containing Melatonin can Potentially Induce Ventricular Arrhythmias in Structurally Normal Hearts: A 2-Patient Report

Lennart J. de Vries et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2017)

Article Pharmacology & Pharmacy

Cardiac fibrosis in the ageing heart: Contributors and mechanisms

Lu Lu et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2017)

Review Biochemistry & Molecular Biology

Mitochondrial bioenergetics decay in aging: beneficial effect of melatonin

Giuseppe Paradies et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Review Neurosciences

Melatonin: Pharmacology, Functions and Therapeutic Benefits

Sylvie Tordjman et al.

CURRENT NEUROPHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Modelling the molecular mechanisms of aging

Mark T. Mc Auley et al.

BIOSCIENCE REPORTS (2017)

Article Pharmacology & Pharmacy

Pharmacokinetics of High-Dose Intravenous Melatonin in Humans

Lars P. H. Andersen et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2016)

Review Geriatrics & Gerontology

Mitochondria and oxidative stress in heart aging

Beatriz Martin-Fernandez et al.

Review Pharmacology & Pharmacy

Update on melatonin receptors: IUPHAR Review 20

Ralf Jockers et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

Redox signaling: An evolution from free radicals to aging

Henry Jay Forman

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Cardiac & Cardiovascular Systems

Melatonin is associated with reverse remodeling after cardiac resynchronization therapy in patients with heart failure and ventricular dyssynchrony

Alberto Dominguez-Rodriguez et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Remodeling of the intercalated disc related to aging in the mouse heart

Tomasz A. Bonda et al.

JOURNAL OF CARDIOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling

Margaux A. Horn et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Review Endocrinology & Metabolism

Melatonin as an antioxidant: under promises but over delivers

Russel J. Reiter et al.

JOURNAL OF PINEAL RESEARCH (2016)

Article Geriatrics & Gerontology

Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders

Showkat Ahmad Ganie et al.

REJUVENATION RESEARCH (2016)

Article Pharmacology & Pharmacy

Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

Lars P. H. Andersen et al.

BMC PHARMACOLOGY & TOXICOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress

Ali A. Sovari

CARDIOLOGY RESEARCH AND PRACTICE (2016)

Review Cardiac & Cardiovascular Systems

Melatonin has multiorgan effects

Lionel H. Opie et al.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2016)

Article Cardiac & Cardiovascular Systems

Mitochondria-derived ROS bursts disturb Ca2+ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study

Qince Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Review Pharmacology & Pharmacy

Clinical pharmacokinetics of melatonin: a systematic review

Nathja Groth Harpsoe et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Review Cardiac & Cardiovascular Systems

How cardiomyocyte excitation, calcium release and contraction become altered with age

Hirad A. Feridaooni et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Review Cardiac & Cardiovascular Systems

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

Giampaolo Morciano et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Review Cardiac & Cardiovascular Systems

Cellular and molecular biology of aging endothelial cells

Anthony J. Donato et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Neurosciences

GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin

Lauren M. Hablitz et al.

JOURNAL OF NEUROSCIENCE (2015)

Article Biochemistry & Molecular Biology

Protective effect of melatonin against myocardial injury induced by epinephrine

Rastislav Vazan et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2015)

Article Cell Biology

Progressive age-associated activation of JNK associates with conduction disruption in the aged atrium

Sandra A. Jones et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2015)

Article Multidisciplinary Sciences

Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy

Sergio Signore et al.

NATURE COMMUNICATIONS (2015)

Letter Biochemistry & Molecular Biology

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

Vadim N. Gladyshev

ANTIOXIDANTS & REDOX SIGNALING (2014)

Editorial Material Biochemistry & Molecular Biology

Redox Regulation of Ion Channels

Ivan Bogeski et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Cardiac & Cardiovascular Systems

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

Mark J. Shen et al.

CIRCULATION RESEARCH (2014)

Letter Cardiac & Cardiovascular Systems

The potential usefulness of serum melatonin level to predict heart failure in patients with hypertensive cardiomyopathy

Alberto Dominguez-Rodriguez et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Role of ATP-Sensitive K+ Channels in Cardiac Arrhythmias

Haruaki Nakaya

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2014)

Review Endocrinology & Metabolism

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

Hong-Mei Zhang et al.

JOURNAL OF PINEAL RESEARCH (2014)

Review Physiology

β-adrenergic receptor responsiveness in aging heart and clinical implications

Nicola Ferrara et al.

FRONTIERS IN PHYSIOLOGY (2014)

Review Biochemistry & Molecular Biology

Redox Control of Cardiac Excitability

Nitin T. Aggarwal et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Editorial Material Cardiac & Cardiovascular Systems

Oxidative Stress and Atrial Fibrillation Finding a Missing Piece to the Puzzle

Kai-Chien Yang et al.

CIRCULATION (2013)

Review Biochemistry & Molecular Biology

Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes

Can M. Sag et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Review Biochemistry & Molecular Biology

Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology

Subhashini Bolisetty et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Cardiac & Cardiovascular Systems

X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca2+]i

Benjamin L. Prosser et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)

Article Multidisciplinary Sciences

Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate

Eric D. Larson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function

Kenkichi Baba et al.

SCIENCE SIGNALING (2013)

Article Cardiac & Cardiovascular Systems

Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells

Zhenghang Zhao et al.

CARDIOVASCULAR RESEARCH (2012)

Review Cardiac & Cardiovascular Systems

Redox Signaling in Cardiac Physiology and Pathology

Joseph R. Burgoyne et al.

CIRCULATION RESEARCH (2012)

Review Cardiac & Cardiovascular Systems

Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias

Paari Dominic Swaminathan et al.

CIRCULATION RESEARCH (2012)

Review Cardiac & Cardiovascular Systems

The Intersection Between Aging and Cardiovascular Disease

Brian J. North et al.

CIRCULATION RESEARCH (2012)

Article Cardiac & Cardiovascular Systems

Reduced Cx43 Expression Triggers Increased Fibrosis Due to Enhanced Fibroblast Activity

John A. Jansen et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2012)

Article Geriatrics & Gerontology

Mechanisms of Arrhythmias and Conduction Disorders in Older Adults

Mahek Mirza et al.

CLINICS IN GERIATRIC MEDICINE (2012)

Editorial Material Cardiac & Cardiovascular Systems

Antioxidant therapy for atrial fibrillation: lost in translation?

Ali A. Sovari et al.

Editorial Material Physiology

Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease

Angela F. Dulhunty et al.

JOURNAL OF GENERAL PHYSIOLOGY (2012)

Review Cardiac & Cardiovascular Systems

Metabolic stress, reactive oxygen species, and arrhythmia

Euy-Myoung Jeong et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)

Review Cell Biology

Melatonin membrane receptors in peripheral tissues: Distribution and functions

Radomir M. Slominski et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

James B. Strait et al.

HEART FAILURE CLINICS (2012)

Review Cardiac & Cardiovascular Systems

Atrial fibrillation in the elderly: the potential contribution of reactive oxygen species

Kurt J. Schillinger et al.

JOURNAL OF GERIATRIC CARDIOLOGY (2012)

Review Physiology

Reactive oxygen species-targeted therapeutic interventions for atrial fibrillation

Ali A. Sovari et al.

FRONTIERS IN PHYSIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Calcium-Calmodulin Kinase II Mediates Digitalis-Induced Arrhythmias

Luis A. Gonano et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2011)

Article Medicine, Research & Experimental

Molecular mechanisms of cardiomyocyte aging

Anna Sheydina et al.

CLINICAL SCIENCE (2011)

Article Endocrinology & Metabolism

The use of high-dose melatonin in liver resection is safe: first clinical experience

Arash Nickkholgh et al.

JOURNAL OF PINEAL RESEARCH (2011)

Article Cardiac & Cardiovascular Systems

Inhibition of c-Src Tyrosine Kinase Prevents Angiotensin II-Mediated Connexin-43 Remodeling and Sudden Cardiac Death

Ali A. Sovari et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

Review Cell Biology

ROS and RNS Signaling in Heart Disorders: Could Antioxidant Treatment Be Successful?

Igor Afanas'ev

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2011)

Article Cardiac & Cardiovascular Systems

Atrial Dilation and Altered Function Are Mediated by Age and Diastolic Function But Not Before the Eighth Decade

Anita C. Boyd et al.

JACC-CARDIOVASCULAR IMAGING (2011)

Letter Cardiac & Cardiovascular Systems

Antioxidant Therapy for Atrial Fibrillation: What Is the Next Step?

Ali A. Sovari

CARDIOLOGY RESEARCH AND PRACTICE (2011)

Article Cardiac & Cardiovascular Systems

Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter

Brett A. English et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)

Review Biochemistry & Molecular Biology

Interplay Between Calcium and Reactive Oxygen/Nitrogen Species: An Essential Paradigm for Vascular Smooth Muscle Signaling

Mohamed Trebak et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Article Cardiac & Cardiovascular Systems

Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion

Carlos A. Valverde et al.

CARDIOVASCULAR RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel

Man Liu et al.

CIRCULATION RESEARCH (2010)

Review Geriatrics & Gerontology

Aging of the autonomic nervous system and possible improvements in autonomic activity using somatic afferent stimulation

Harumi Hotta et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2010)

Article Biochemistry & Molecular Biology

Oxidative Stress Inhibits Vascular KATP Channels by S-Glutathionylation

Yang Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cardiac & Cardiovascular Systems

Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization

David A. Brown et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

Giuseppe Petrosillo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress

Norishige Morita et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death

Andriy E. Belevych et al.

CARDIOVASCULAR RESEARCH (2009)

Article Cardiac & Cardiovascular Systems

Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure

Can M. Sag et al.

CIRCULATION-HEART FAILURE (2009)

Review Pharmacology & Pharmacy

Clinical Aspects of Melatonin in the Acute Coronary Syndrome

Alberto Dominguez-Rodriguez et al.

CURRENT VASCULAR PHARMACOLOGY (2009)

Review Cardiac & Cardiovascular Systems

A Novel Mechanism for the Treatment of Angina, Arrhythmias, and Diastolic Dysfunction: Inhibition of Late I-Na Using Ranolazine

Lars S. Maier

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Aged atria: electrical remodeling conducive to atrial fibrillation

Wen Dun et al.

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY (2009)

Article Endocrinology & Metabolism

A novel electrophysiologic effect of melatonin on ischemia/reperfusion-induced arrhythmias in isolated rat hearts

Emiliano Raul Diez et al.

JOURNAL OF PINEAL RESEARCH (2009)

Review Cell Biology

Oxidative stress as a mediator of cardiovascular disease

Maqsood M. Elahi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2009)

Article Cardiac & Cardiovascular Systems

Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca2+ Leak in Chronic Heart Failure

Dmitry Terentyev et al.

CIRCULATION RESEARCH (2008)

Article Biochemistry & Molecular Biology

Molecular mechanisms of inherited arrhythmias

Cordula M. Wolf et al.

CURRENT GENOMICS (2008)

Article Endocrinology & Metabolism

Utility of melatonin to treat surgical stress after major vascular surgery -: a safety study

Bulent Kucukakin et al.

JOURNAL OF PINEAL RESEARCH (2008)

Review Cardiac & Cardiovascular Systems

Atrial fibrosis: Mechanisms and clinical relevance in atrial fibrillation

Brett Burstein et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)

Article Multidisciplinary Sciences

A systematic look at an old problem

Thomas B. L. Kirkwood

NATURE (2008)

Article Neurosciences

Autonomic control of the aging heart

David M. Kaye et al.

NEUROMOLECULAR MEDICINE (2008)

Review Neurosciences

Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways

Seithikurippu R. Pandi-Perumal et al.

PROGRESS IN NEUROBIOLOGY (2008)

Article Pharmacology & Pharmacy

Evidence for the regulation of L-type Ca2+ channels in the heart by reactive oxygen species:: Mechanism for mediating pathology

Livia C. Hool

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2008)

Review Biochemistry & Molecular Biology

Changes in DNA repair during aging

Vera Gorbunova et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Cardiac & Cardiovascular Systems

Intravenous iron reduces NT-Pro-Brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency

Jorge Eduardo Toblli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

Age-related down-regulation of HCN channels in rat sinoatrial node

Xin Huang et al.

BASIC RESEARCH IN CARDIOLOGY (2007)

Article Medical Laboratory Technology

Oxidative stress markers are associated with persistent atrial fibrillation

Robert B. Neuman et al.

CLINICAL CHEMISTRY (2007)

Article Cardiac & Cardiovascular Systems

Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure

Mamoru Mochizuki et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)

Review Physiology

Calcium and arrhythmogenesis

Henk E. D. J. Ter Keurs et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Pharmacology & Pharmacy

Ageing to arrhythmias: conundrums of connections in the ageing heart

Sandra A. Jones

JOURNAL OF PHARMACY AND PHARMACOLOGY (2006)

Article Biochemistry & Molecular Biology

Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes

Lijun Liu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Review Cardiac & Cardiovascular Systems

Redox regulation of cardiac calcium channels and transporters

Aleksey V. Zima et al.

CARDIOVASCULAR RESEARCH (2006)

Article Pharmacology & Pharmacy

Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction

Yejia Song et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Review Biochemistry & Molecular Biology

Melatonin - Nature's most versatile biological signal?

S. R. Pandi-Perumal et al.

FEBS JOURNAL (2006)

Review Geriatrics & Gerontology

Melatonin and sleep in aging population

SR Pandi-Perumal et al.

EXPERIMENTAL GERONTOLOGY (2005)

Article Chemistry, Multidisciplinary

Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes

JH Ma et al.

ACTA PHARMACOLOGICA SINICA (2005)

Article Cardiac & Cardiovascular Systems

Defective cardiac ryanodine receptor regulation during atrial fibrillation

JA Vest et al.

CIRCULATION (2005)

Review Biochemistry & Molecular Biology

Understanding the odd science of aging

TBL Kirkwood

Review Clinical Neurology

The basic physiology and pathophysiology of melatonin

B Claustrat et al.

SLEEP MEDICINE REVIEWS (2005)

Review Physiology

Basic mechanisms of cardiac impulse propagation and associated arrhythmias

AG Kléber et al.

PHYSIOLOGICAL REVIEWS (2004)

Article Cardiac & Cardiovascular Systems

Effects of aging on cardiovascular responses to parasympathetic withdrawal

JR Stratton et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2003)

Review Cardiac & Cardiovascular Systems

Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart

RJ Reiter et al.

CARDIOVASCULAR RESEARCH (2003)

Article Neurosciences

Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X

A Altun et al.

NEUROSCIENCE LETTERS (2002)

Review Cardiac & Cardiovascular Systems

Cardiac gap junctions and connexins: their role in atrial fibrillation and potential as therapeutic targets

HMW van der Velden et al.

CARDIOVASCULAR RESEARCH (2002)

Article Cardiac & Cardiovascular Systems

Adrenergic-cholinergic interaction that modulates repolarization in the atrium is altered with aging

EA Sosunov et al.

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2002)

Article Cardiac & Cardiovascular Systems

Alterations in properties of L-type Ca channels in aging rat heart

IR Josephson et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2002)

Article Endocrinology & Metabolism

Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum

G Escames et al.

JOURNAL OF NEUROENDOCRINOLOGY (2001)

Article Biophysics

Multiple binding sites for melatonin on Kv1.3

Z Varga et al.

BIOPHYSICAL JOURNAL (2001)