期刊
ORGANIC LETTERS
卷 23, 期 11, 页码 4379-4384出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01315
关键词
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资金
- National Nature Science Foundation of China [21472137, 21772142, 21961142015]
- National Key Research & Development Program of China [2019YFA0905100]
The study presents a Cu-bisoxazoline-catalyzed enantioselective decarboxylative aldol reaction for the synthesis of a series of phaitanthrin A analogues, with both enantiomers of the products obtainable with good to high enantioselectivity by simply changing copper salts. Tentative stereochemical models based on X-ray crystallographic analysis of chiral Cu(II)-bisoxazoline complexes explain the observed counteranion-induced switching in enantioselectivity.
Cu-bisoxazoline-catalyzed enantioselective decarboxylative aldol reaction of tryptanthrin with aryl-substituted beta-keto acids is developed, providing a straightforward approach to deliver a series of phaitanthrin A analogues. Both enantiomers of the products can be obtained with good to high enantioselectivity in the presence of a single chiral ligand by simply changing the copper salts. Based on the X-ray crystallographic analysis of chiral Cu(II)-bisoxazoline complexes, the tentative stereochemical models are presented to account for the observed counteranion-induced switching in enantioselectivity.
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