期刊
ORGANIC LETTERS
卷 23, 期 10, 页码 4034-4039出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01253
关键词
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资金
- National Natural Science Foundation of China [91856104, 21871145]
- Tianjin Applied Basic Research Project and Cutting-Edge Technology Research Plan [19JCZDJC37900]
- Fundamental Research Funds for the Central Universities [63191601]
The study successfully demonstrated the dual C-H annulation of N-aromatic imidazole using a base-metal Ni catalyst, yielding a range of desired polycyclic aza-quinolines in 48-95% yields. The use of bifunctional phosphine oxide ligand was crucial for the success of the reaction.
Transition metal catalyzed dual C-H activation and annulation with alkynes was an attractive protocol to construct polycyclic pi-extended structures. However, most of them were dominated by noble metal catalysts. Disclosed herein was the study of base-metal Ni-catalysis for dual C-H annulation of N-aromatic imidazole, which produced a range of desired polycyclic aza-quinolines in 48-95% yields. The use of bifunctional phosphine oxide ligand proved to be critical for success.
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