期刊
ORGANIC LETTERS
卷 23, 期 9, 页码 3604-3609出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00999
关键词
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资金
- National Natural Science Foundation of China [21801163, 51973107]
- STU Scientific Research Foundation for Talents [NTF18003]
- Chemistry and Chemical Engineering Guangdong Laboratory [1922003]
- 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant [2020LKSFG05A]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme 2019 [GDUPS2019]
In this study, the catalytic Markovnikov-selective hydrothiolation of alkenes was achieved using photoredox/cobalt catalysis with the assistance of directing groups, resulting in excellent regioselectivity of the products.
In contrast with the well-developed radical thiol-ene reaction to access anti-Markovnikov-type products, the research on the catalytic Markovnikov-selective hydrothiolation of alkenes is very restricted. Because of the catalyst poisoning of metal catalysts by organosulfur compounds, limited examples of transition-metal-catalyzed thiol-ene reactions have been reported. However, in this work, a directing-group-assisted hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis is found to proceed smoothly to afford Markovnikov-type sulfides with excellent regioselectivity.
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