期刊
ORGANIC LETTERS
卷 23, 期 9, 页码 3287-3293出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00712
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-
资金
- NSFC [21632003, 21871116]
- key program of Gansu province [17ZD2GC011]
- 111' program from the MOE of P.R. China
A novel one-pot triple-reaction strategy for the asymmetric construction of polycyclic skeletons with multiple consecutive chiral centers has been reported, resulting in the formation of a wide range of polycyclic tetrahydroquinoline derivatives with good results. This transformation involves the successive formation of five chemical bonds and five consecutive chiral centers.
A novel one-pot triple-reaction strategy for the asymmetric construction of polycyclic skeletons with multiple consecutive chiral centers through aza-Michael/Michael/Wittig/ketyl radical addition/esterification processes is reported. A wide range of polycyclic tetrahydroquinoline derivatives were smoothly obtained from easily available starting materials with good results (up to 80% yield, >20:1 dr, >99% ee) under mild conditions. In this transformation, five chemical bonds and five consecutive chiral centers were successively formed.
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