期刊
ORGANIC LETTERS
卷 23, 期 7, 页码 2578-2583出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00489
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-
资金
- Deutsche Forschungsgemeinschaft [SCHN 441/11-2, 14-1]
A synthetic method has been developed for the stereoselective (3 + 3)-cycloannulation of in situ generated carbonyl ylides with indolyl-2-methides, resulting in oxa-bridged azepino[1,2-a]indoles in one step. The products, with three stereogenic centers, were obtained with good stereoselectivity and yields, showcasing valuable heterocyclic complexity.
A stereoselective (3 + 3)-cycloannulation of in situ generated carbonyl ylides with indolyl-2-methides has been developed furnishing oxa-bridged azepino[1,2-a]indoles within one synthetic step. This process is enabled by cooperative rhodium and chiral phosphoric acid catalysis to produce both transient intermediates in separate catalytic cycles. The products comprising three stereogenic centers were obtained with good stereoselectivity and yields and display valuable heterocyclic complexity.
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