期刊
ORGANIC LETTERS
卷 23, 期 9, 页码 3384-3388出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00857
关键词
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资金
- National Natural Science Foundation of China [21772202, 21831008, 22025109]
- Beijing Municipal Science & Technology Commission [Z191100007219009]
- Beijing National Laboratory for Molecular Sciences [BNLMS-CXXM-201901]
- K. C. Wong Education Foundation
Researchers have developed a novel trio of Me2Zn/ AlCl3/AgOTf to establish manganese catalysis, enabling the [3 + 2] cyclization of ketones with isocyanates via inert C-H activation to access 3-alkylidene phthalimidines in a straightforward manner.
Stoichiometric cyclomanganation of aromatic ketones and further reactions of the thus-formed manganacycles with isocyanates were first reported by Kaesz and Liebeskind in 1975 and 1990, respectively. The buildup of a closed manganese catalytic cycle for the reaction of ketones and isocyanates remains an unsolved problem. Herein, an unprecedented trio of Me2Zn/ AlCl3/AgOTf is developed to build up manganese catalysis, which enables the [3 + 2] cyclization of ketones with isocyanates via inert C-H activation to access 3-alkylidene phthalimidines in a straightforward manner unachieved by other transition metal catalyses.
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