4.8 Article

Genome Mining-Driven Discovery of 5-Methylorsellinate-Derived Meroterpenoids from Aspergillus funiculosus

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Summary: Fungal meroterpenoids are secondary metabolites with diverse chemical structures and potential bioactivities, classified into four categories mainly consisting of polyketide-terpenoids and shikimate-terpenoids. Basidiomycota are major producers of meroterpenoids, with genera like Ganoderma, Penicillium, Aspergillus, and Stachybotrys being dominant. Around 56% of meroterpenoids exhibit significant bioactivities, and some have been developed into clinically used drugs, indicating their potential in drug discovery.

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