期刊
ORGANIC LETTERS
卷 23, 期 11, 页码 4261-4266出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01211
关键词
-
资金
- National Natural Science Foundation of China [81971674]
- Science Fund for Distinguished Young Scholars of Fujian Province [2019J06006]
- Fundamental Research Funds for the Central Universities [20720180050]
- Scientific Research Foundation of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics [2016ZY002]
This method achieves high radiochemical yield late-stage direct F-18 labeling of bare biomolecules containing common active groups, with spontaneity and site-selectivity attributed to higher rates of nucleophilic substitution reactions on phosphonates. Rapid access to many medicinally significant F-18-labeled biomolecules is achieved manually or automatically with high radiochemical yields and molar activities.
We describe a high radiochemical yield late-stage direct F-18-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other electrophiles by F- at various hydrogen bond forms. Rapid access to many medicinally significant F-18-labeled biomolecules is achieved at 21-68% radiochemical yields and 35.9-55.1 GBq mu mol(-1) molar activities both manually or automatically.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据